Crybaby Pierrot's Wedding

Kanami is an apprentice pierrot and dreams of making people laugh. She falls in love with Yosuke, who is a dialysis patient. He forgets to smile. To make Yosuke smile, Kanami decides to have a smile no matter what. Yosuke begins to have feelings to her and they decide to marry. On the day before their wedding Yosuke collapses.
(Source: AsianWiki)
~~ Adapted from the non-fiction novel "Crybaby Pierrot's Wedding" (泣き虫ピエロの結婚式) by Mochizuki Miyuki (望月美由紀).